Abstract: Alzheimer's disease (AD) is a neurodegenerative disease that occurs in senescence, which could be the main risk factor to lead to senile dementia. Currently, there is no effective strategy in the prevention and treatment of AD. Numerous studies have confirmed that exercise can promote learning and memory, including the patients with cognitive dysfunction or animals. The mechanisms underlying these benefits have been explored using animal models of AD. Accumulating studies show that exercise reinstates the testing animal hippocampal's function by inhibiting the deposition of Aβ and tau hyperphosphorylation, ameliorating the epigenetics mechanism of AD, and enhancing the expression of brain-derived neurotrophic factor (BDNF) and other growth factors that promote neurogenesis and synaptic plasticity. In addition, researchers have found that exercise may counteract aged or AD-associated declines in mitochondrial and immune system function.