Abstract: The recent research advances around irisin-mediated exercise intervention in neuropsychiatric disorders are presented. The functions of irisin in promoting the production of neurotrophic factors, improving neuronal function, promoting neuronal proliferation and neurogenesis, improving energy metabolism and oxidative stress levels in the brain, and reducing neurotoxic effects by acting on the central nervous system are systematically reviewed. Furthermore, the mechanism of action of irisin signaling pathway in exercise to improve neuropsychiatric disorders such as major depressive disorder, Alzheimer's disease and Parkinson's syndrome was explained from the peripheral pathway. It was found that irisin plays a positively regulatory role in improving neuropsychiatric diseases, and the irisin level induced by exercise varies with the intensity of exercises. There exists an endocrine pathway between muscles and brain, in which the skeletal muscle as an endocrine organ can regulate the health and homeostasis of the brain, and the signaling pathway of irisin may mediate the physical exercise's intervening in neuropsychiatric diseases. The irisin, produced by the exercised-induced skeletal muscle's contraction, may regulates the BDNF level of the brain, which further exerts a vital role in the regulation of emotion, cognition and neurological functions.