Abstract: The beneficial effects of exercise on health are well documented by evidence-based medicine, and it has been suggested that the health promotion of exercise is at least in part attributable to the "crosstalk" or "interaction" between organs (tissues) caused by exerkines released into the circulation by organs (tissues) during exercise. The classification, function and mechanism of exerkines are summarized, and the relationship between the myokines, adipokines, osteokines and hepatokines released by exercise and the occurrence and development of diseases is explained. It is believed that exercise-induced myokines, adipokines, osteokines and hepatokines can have a wide range of effects on the shape, structure, function and metabolism of the human body through "self-crosstalk" and "crosstalk" between organs (tissues) and organs (tissues), and participate in the maintenance of individual health. The effect of this crosstalk depends on the form of exercise, exercise intensity, exercise duration, exercise frequency and other factors. The conclusions can provide a new perspective for the understanding of the mechanism of exercise health promotion.