Abstract: The cross-border and complexity of sports-medicine integration determine the inevitability of promoting its collaborative innovation. From the perspective of actor-network theory, the integration and collaborative innovation of sports-medicine integration is essentially a translation practice process that takes governments at all levels and sports and medical administrative departments as the core, and enterprises, social organizations, universities and research institutes, communities, the public and media as innovative entities, and ideology, policy, culture, data, technology, and funding as innovative elements, which combines to act as actors. This process includes problem presentation, benefit allocation, mobilization, and resolution of objections. At present, the innovation still faces multiple difficulties, such as weak anchoring of translation visions caused by institutional suspension, limited actor initiative caused by structural constraints, hindered synergy in translation caused by subject differentiation, and insufficient vectors for translation caused by limited space. In this regard, we can start from the aspects of institutional optimization, structural adjustment, integration of subjects and space creation to crack the translation dilemma, promote the construction of actor-network, and deepen the collaborative innovation of sports-medicine integration.