Abstract: This study reviewed the literature on cardiac protection from exercises in terms of the cardiac, remote organs and central nervous system. The mechanism is explored, which has significance in improving the mass and heart-disease patients' cognition, understanding and trusting exercises' role in cardiac protection, push the combination of the basic research and clinic application, etc. Exercise directly reduces the risk of heart disease, improves heart damage, and optimizes cardiac metabolism and function. At the same time, exercise can indirectly protect the heart through metabolites of the intestinal flora and "exerkines" from the skeletal muscle, kidney, liver, and adipose tissue. Based on the comprehensive neural regulatory network, exercise can improve cardiac function by regulating cardiac autonomic nerve activity through the "brain-heart" axis, "gut-brain" axis and "liver-brain" axis, and optimize cardiovascular reflexes. On this basis, "exercise simulators", experimental animal models, telerehabilitation safety, efficient and accurate exercise guidelines, etc., are the opportunities and challenges faced by cardiac exercise rehabilitation when the basic research will be transferred into clinic practice. Notably, the advancement of neurocardiology is of paramount importance in elucidating the mechanism of "synchronous rehabilitation for brain and heart" in exercise.