Abstract: Alzheimer's disease(AD) is a neurodegenerative disease with insidious onset characterizing clinically by chronic and progressive dementia, personality change and mental disorder. Without clear cause, AD is regarded as a disease induced by multiple factors, such as Aβ cascade, neuro-inflammation and glucose metabolism disturbance, and so on. Astrocytes, as the most number, richest functions and variety of structure cell-style in the central nervous system(CNS), plays key roles in Aβ metabolism, neuroinflammation and glucose metabolism disturbance, becoming the crucial target to prevent or postpone the AD. Physical exercise can improve AD via multiple aspects as an important treatment or intervention to astrocytes. The present review elaborates the mechanisms among AD, astrocytes and physical exercise in order to provide new views to prevent and alleviate AD.