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赵璨, 王人卫, 高炳宏. 不同类型运动干预非酒精性脂肪性肝病患者肝内脂质的方式、剂量与途径[J]. 上海体育学院学报 , 2021, 45(6): 80-92. DOI: 10.16099/j.sus.2021.06.006
引用本文: 赵璨, 王人卫, 高炳宏. 不同类型运动干预非酒精性脂肪性肝病患者肝内脂质的方式、剂量与途径[J]. 上海体育学院学报 , 2021, 45(6): 80-92. DOI: 10.16099/j.sus.2021.06.006
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ZHAO Can, WANG Renwei, GAO Binghong. Method, Dose and Pathway of Different Exercise Types to Intrahepatic Lipid in Patients with Nonalcoholic Fatty Liver Disease[J]. Journal of Shanghai University of Sport, 2021, 45(6): 80-92. DOI: 10.16099/j.sus.2021.06.006
Citation: ZHAO Can, WANG Renwei, GAO Binghong. Method, Dose and Pathway of Different Exercise Types to Intrahepatic Lipid in Patients with Nonalcoholic Fatty Liver Disease[J]. Journal of Shanghai University of Sport, 2021, 45(6): 80-92. DOI: 10.16099/j.sus.2021.06.006
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不同类型运动干预非酒精性脂肪性肝病患者肝内脂质的方式、剂量与途径

Method, Dose and Pathway of Different Exercise Types to Intrahepatic Lipid in Patients with Nonalcoholic Fatty Liver Disease

    摘要
  • 摘要:
      目的  探讨不同类型运动干预降低非酒精性脂肪性肝病（NAFLD）患者肝内脂质含量的靶向作用和量效关系。
      方法  在Web of Science、PubMed、中国知网、万方及维普网等数据库检索文献，依据纳入与排除标准最终筛选出21篇文献进行分析，比较有氧运动、抗阻运动、高强度间歇运动及组合运动干预NAFLD患者的方案及效果差异。
      结果  有氧运动主要通过分解消耗脂肪降低肝内脂质含量，抗阻运动主要通过促进骨骼肌吸收游离脂肪酸减少肝内脂质堆积。虽然目前有氧运动联合抗阻运动的效果与单纯有氧运动或抗阻运动的短期效果在统计学上难以区分，但从长期效果看，结合抗阻运动能保持骨骼肌对游离脂肪酸的利用率，高强度间歇运动可有效改善肝硬化和恢复Kupffer细胞功能。
      结论  有氧运动、抗阻运动和高强度间歇运动单独干预或组合干预均可降低NAFLD患者的肝内脂质含量，但剂量选择和靶向作用不同，高强度间歇运动相对更高效、省时，推荐NAFLD患者采取组合干预形式。

     

    Abstract:
      Objective  To analyze the targeting effect of different exercises on intrahepatic lipid(IHL) content of patients with non-alcoholic fatty liver disease(NAFLD) and the exercise dose levels.
      Methods  By searching literature in the databases such as Web of Science(WoS), PubMed and CNKI etc., 21 articles were filtered and analyzed according to inclusion & exclusion criteria eventually. The program and effect of aerobic exercise (AE), resistance exercise (RE) and high-intensity interval training(HⅡT) and combination of exercise intervention were compared in NAFLD patients.
      Results  AE reduced IHL content by consuming adipose tissue; RE reduced the accumulation of IHL by promoting the absorption of non-esterified fatty acid(NEFA) in skeletal muscles mainly with the effective increase of muscle mass and strength.Although the short-term effect of AE+RE was statistically indistinguishable from AT or RE alone, combination of RE could maintain the utilization rate of NEFA by skeletal muscle and promote the formation of a virtuous cycle of systemic metabolism as a long-term benefit.
      Conclusions  Different types of exercise can reduce intrahepatic lipid(IHL) content of patients with NAFLD, but the dose and targeted role are different.HⅡT is more efficient and timesaving.The combination of the both is still recommended for NAFLD patients when time and space conditions are available.

     

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